Start studying Innere Medizin. Zidovudine. Learn reverse transcriptase with free interactive flashcards.

Start studying Antiretroviral Agents: *Reverse Transcriptase Inhibitors*. Match. Start studying Pharma Nizza-Hannover Projekt. Inhibit HIV DNA polymerase replication. - inhibits mitochondrial DNA synthesis which may lead to PERIPHERAL NEUROPATHY- inactivated by acid, given in a bufferedd prep on an empty stomach - dideoxythymidine; phosphorylated, incorporated into DNA; inhibits reverse transcriptase- used in adults with advanced HIV who do not tolerate or deteriorate on other therapy - DIDEOXYCYTIDINE, inhibits reverse transcriptase and terminates DNA chain What 4 drugs are associated with peripheral neuropathy?-PERIPHERAL NEUROPATHY, especially if DM, alcoholism, Vit. When should the RTI's be discontinued?- deoxythymidine analogue, converted intracellularly to active triphosphate which becomes incorporated into DNA - SHORT ACTION (3 hrs in tissue), usually adminstered 5x/day - HIV infection, AIDS or advanced AIDS releated complex (ARC) - MYELOSUPPRESSION - ANEMIA, NEUTROPENIA are most serious toxiciteies- may increase toxicity when used with drugs that are NEUROTOXIC, NEPHROTOXIC OR THAT AFFECT BONE MARROW (i.e.

Write. Ellembee PLUS. Flashcards. STOPS growth - nucleosde analogues - inhibit transcription of viral RNA into double stranded DNA - non-nucleoside reverse transcriptase inhibitors: bind directly to reverse transcriptase and prevent conversion of RNA to double strand; DO NOT REQUIRE PHOSPHORYLATION for activity; COMBINED WITH ZIDOVUDINE or other NRTIs: resistance develops rapidly if used alone! Less common side effect of NRTIs. Spell. Nucleoside reverse transcriptase inhibitors (NRTI) STUDY. non-nucleoside reverse transcriptase inhibitor protease inhibitor nucleoside reverse transcriptase inhibitor. Terms in this set (16) Use of NRTIs. B12 deficiency - guanosine analogue, very effective reverse transcroptase inhibitor; resistance develops slowly- SERIOUS HYPERSENSITIVITY REACTIONS occur in 5% of pts. 80%. CD4. PLAY. Learn vocabulary, terms, and more with flashcards, games, and other study tools. What are the 2 groups of reverse transcriptase inhibitors and what is the MOA of each?- nucleosde analogues - inhibit transcription of viral RNA into double stranded DNAWhat side effects are rare but serious with reverse transcriptase inhibitors? Created by.

Research has shown postexposure prophylaxis given within one to two hours after injury can decrease the risk of infection by what percent? dapsone, pentamidine, amphotericin B, vincristine, vinblastine, doxorubicin, interferon)- very well tolerated; mild side effects include headache, fatigue, insomnia, GI upset- Adenosine analogue, active against HIV-1 which has become resistant to other drugs- cytosine analogue, very cimilar to lamivudine but more potent against HIV- DOC, combined with tenofovir, for Tx of naive pts. Who is more susceptible? Severe hepatomegaly + steatosis... Drug induced m…nucleoside reverse transcriptase inhibitors and non-nucleoside reverse transcriptase inhibitorsgeneric name trade name ... efavirenz (sustiva)... nevirapine (viram…mistaken for a nucleotide used to form DNA. - all metabolized by CYP3A4 and have …

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Learn vocabulary, terms, and more with flashcards, games, and other study tools. STOPS growthmistaken for a nucleotide used to form DNA.

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Effect of NRTIs in the body. HIV infection and AIDS. What cells are responsible for the immune response in the body? ; Sx include fever, malaise, skin rash, chills, sore throat, difficulty breathing - Stevens-Johnson syndrome - worse if treated with corticoseroids; discontinue drug- inhibits CYP3A: numerous pharmacokinetic drug interactions - rash (very common), nausea headache and elevated serum aminotransferase levels

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