5 Similar Profiles; Ipilimumab Medicine & Life Sciences. Dr. Sharma is a nationally and internationally renowned physician scientist whose research work is focused on investigating mechanisms and pathways within the immune system that facilitate tumor rejection, with subsequent clinical benefit, or elicit resistance to immune checkpoint therapy. 2017 Jan 25. pii: S1470-2045(17)30065-7. doi: 10.1016/S1470-2045(17)30065-7. All Rights Reserved Sharma spent 3 months in hospital in a coma following an accidentThe work was led by Padmanee Sharma. Her subsequent experiments with transgenic mice showed that the ICOS molecule and its ligand (ICOSL) are a crucial player in optimising the anti-tumour responses mediated by the anti-CTLA-4 antibody.CI Liakou et al, ‘CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi T cells to shift the ratio of effector to regulatory T cells in cancer patients’, Sharma spent 3 months in hospital in a coma following an accidentPaper published indicating thymus-leukaemia antigen, a cell-surface marker, stimulates T cells to destroy specific target cellsSharma took up clinical residency in internal medicineSharma completed her medical training and doctorateSharma received ASCO Young Investigator Award to carry out clinical trials with NY-ES0-1 cancer vaccineSharma took up position at University of Texas MD Anderson Cancer CenterSharma discovered some bladder cancer cells expressed the marker NY-ESO-1 providing means for cancer vaccineInducible co-stimulator (ICOS) protein found to enhance anti-CTLA-4 treatment in destruction of cancer cellsSharma received the Emil Frei Award for Excellence in Translational ResearchSharma elected to join the American Society for Clinical InvestigationRespond to or comment on this page on our feeds on Sharma is a leading figure in the field of cancer immunology. She was the first to show the importance of the inducible co-stimulator (ICOS) protein in the destruction of cancer cells. Similar articles. Nivolumab Medicine & Life Sciences. They were first published Chrysoula I Liakou, Ashish Kamat, Derek Ng Tang, Hong Chen, Jingjing Sun, Patricia Troncoso, Christopher Logothetis, and Padmanee Sharma, ‘CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi T cells to shift the ratio of effector to regulatory T cells in cancer patients’, PNAS USA, 105/39 (Sept 2008), 14987-92.Inducible co-stimulator (ICOS) protein found to enhance anti-CTLA-4 treatment in destruction of cancer cellsSharma received the Emil Frei Award for Excellence in Translational ResearchSharma elected to join the American Society for Clinical Investigation Immunotherapy Medicine & Life Sciences. To her complete surprise, nine months into her clinical residency, Sharma was contacted by Lloyd Old. Abraham's Tent, Inc. is an education non-profit started by Dr. Padmanee Sharma and Dr. Jim Allison dedicated to providing an education that supports future success and equal opportunities for children in need in Guyana and the United States. He was a key pioneer of tumour immunology who led the development of the tuberculosis vaccine (BCG) for the treatment of bladder cancer, approved in 1990.Sharma was the first scientist to show that anti-CTLA-4 therapy increases the frequency of T cells that express the inducible co-stimulator (ICOS) protein, with subsequent work showing that ICOS+ T cells were necessary for optimal destruction of the tumour cells. T-Lymphocytes Medicine & Life Sciences. She has won multiple awards during her career including the 2012 MD Anderson Cancer Center Faculty Scholar Award and the 2008 Melanoma Research Alliance Young Investigator Award.
Lancet Oncol. Biography . Padmanee Sharma is a leading figure in oncology, specialising in renal, bladder and prostate cancer. Her prime focus is to understand the mechanisms and pathways within the immune system responsible for tumour rejection. Read our updated The team's finding appeared in P. Sharma et al, ‘Thymus-leukaemia antigen interacts with T cells and self-peptides’, Journal Immunology, 156 (1996), 987-96.Paper published indicating thymus-leukaemia antigen, a cell-surface marker, stimulates T cells to destroy specific target cellsSharma took up clinical residency in internal medicineSharma completed her medical training and doctorateSharma received ASCO Young Investigator Award to carry out clinical trials with NY-ES0-1 cancer vaccineSharma took up position at University of Texas MD Anderson Cancer CenterPadmanee Sharma et al, ‘Frequency of NY-ESO-1 and LAGE-1 expression in bladder cancer and evidence of a new NY-ESO-1 T-cell epitope in a patient with bladder cancer’, Cancer Immunology, 3 (Dec 13 2003), 19.Sharma discovered some bladder cancer cells expressed the marker NY-ESO-1 providing means for cancer vaccineThis was first observed by Padmanee Sharma. All were forced to work in conditions reminiscent of slavery. She has participated in 54 research outputs since 1996, focusing primarily on immunotherapy in her collaborations with Dr. James P. … [Epub ahead of print] PMID: 28131785. The rest, including Sharma’s family, remained, constituting the largest population in Guyana.Eager to escape the tensions at home and the strong patriarchal attitudes of her father, the one place where Sharma found a haven of peace when she arrived in New York was at school. Sharma is a Cancer Research Institute Investigator who has tested new prostate cancer immunotherapies, looking for differences in T cell subsets and function between pre-therapy blood and tissue samples versus post-therapy blood and tissue samples.

Padmanee Sharma (born June 26, 1970) is an immunologist and oncologist at the University of Texas MD Anderson Cancer Center in Houston, Texas.

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